Salivary gamma glutamyl transpeptidase as a biomarker in patients with oral squamous cell carcinoma and precancerous lesions

Background: Gamma‑glutamyl transpeptidase (GGT) is a membrane‑bound enzyme, which not normally expressed in oral epithelial tissues. The present study evaluated salivary gamma‑glutamyl as biomarker squamous cell carcinoma and precancerous lesions.Materials & Methods: 78 subjects were divided into 3 groups of 26 each. Group I healthy subjects, group II had lesions III (OSCC). In all unstimulated saliva samples collected subjected to estimation enzyme. Results: 13 males females, 20 6 females 18 8 females. mean GGT level was 16.4 IU/L, 52.6 IU/L 73.2 IU/L. difference significant (P< 0.05). Conclusion: Salivary gamma-glutamyl transferase higher increased patients with OSCC premalignant lesions, thus can be used effectively tumor marker.